Transglutaminases Multiple Functional Modifiers and Targets for New Drug Discovery

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Title:

Author:

Hitomi, Kiyotaka. editor.

ISBN:

9784431558255

Edition:

1st ed. 2015.

Physical Description:

VIII, 391 p. 85 illus., 37 illus. in color. online resource.

Contents:

1 Structure of Transglutaminases. Unique Features Serve Diverse Functions -- 2 Control of Tg Functions Depending on their Localization -- 3 Preferred Substrate Structure of Transglutaminases -- 4 Insights into Transglutaminase 2 Function Gained from Genetically-Modified Animal Models -- 5 Tranglutaminase in Invertebrates -- 6 Formation of Integrin-Binding Site on Polymer of Transglutamination -- 7 Transglutaminase 2-Mediated Gene Regulation -- 8 The Role of Transglutaminase Type 2 in the Regulation of Autophagy -- 9 Transglutaminase 2 and Celiac Disease -- 10 Transglutaminase ii and Metastasis: How Hot is the Link?- 11 Transglutaminases: Expression in Kidney and Relation to Kidney Fibrosis -- 12 Transglutaminases in Bone Formation and Bone Matrix Stabilization -- 13 Transglutaminases and Neurological Diseases -- 14 Transglutaminase; Mechanism by Oxidative Stress -- 15 Blood Coagulation Factor Xiii : A Multifunctional Transglutaminase -- 16 Inhibition of Transglutaminase -- 17 Substrate Engineering of Microbial Transglutaminase for Site-Specific Protein Modification and Bioconjugation.

Subject Term:

Pharmaceutical chemistry.

Added Author:

Added Corporate Author:

SpringerLink (Online service)