Part I. Introduction to Drug-Drug Interactions -- 1. Let's Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions -- 2. Pharmacodynamic Interactions:  Core Concepts -- 3. Pharmacokinetic Interactions:  Core Concepts -- 4. A Brief Treatise On The Area Under The Curve -- Part II. Introduction to Drug-Drug Interactions:  Brief Review of CYP450 Enzymes, UGTs, and Transporters -- 5. CYP2D6:  Where It All Began -- 6. CYP2E1:  The Anesthesia Enzyme -- 7. CYP3A4:  The Workhorse -- 8. CYP1A2:  The Switch-hitter -- 9. CYP2B:   2B or Not 2B?- 10. CYP2C9:  The Support Crew I -- 11. CYP2C19:   The Support Crew II -- 12. UGTs:  Conjugating Cousins -- 13. The Cytochrome P450 System In Disease States-A Brief Review -- PART III. Drug-Drug Interactions:  Paradigms and Core Concepts -- 14. P-glycoprotein and OATP Transporters -- 15. The  "Fatal" Forty -- 16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions -- 17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma -- 18. Pharmacogenomics -- 19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important -- 20. The Lawyers Can Read, Too:  Case Presentations from the Courtroom -- Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents -- 21. Introduction -- 22. That Sums It Up -- 23. 1+1+1+1=? -- 24. A Delayed Surgeon Is A "Dismayed" Surgeon? -- 25. Relax, It's Only Gentamicin -- 26. Jaundice After Surgery -- 27. Everybody Clear? -- 28. The Hemodynamic Hole -- 29. Alpha-2 To The Rescue But Beware Bradycardia -- 30. Hot Stuff! -- Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents -- 31. Introduction -- 32. How to Successfully Occlude an Intravenous Line -- 33. A Curious Cause of Seizures -- 34. Magnesium Mama And The Mad Dad -- 35. Dexy's Midnight Spinal -- Part VI. Drug-Drug Interactions Involving Local Anesthetics -- 36. Introduction -- 37. Comfortably Numb -- 38. Naturally Occurring And Nasty -- 39. LOL-LOL:  Little Old Lady-Lots of Lido -- 40. The Spinal Countdown -- 41.  Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity?  Smoking Gun I -- 42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity?  Smoking Gun II -- 43. A Perfect Storm? -- 44. Shake Rattle and Roll -- 45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult -- 46. Fatal Pain Relief -- 47. Lipid Lifesaver -- Part VII. Drug-Drug Interactions Involving Opioids -- 48. Introduction -- 49. No 'Subs'titute for Sobriety -- 50. A Needle And The Damage Done -- 51. Dad's Not Having Much Pain -- 52. Royal Flush -- 53. The Worry That's Always With Us:  Afternoon Nap -- 54. The Bawling Baby -- 55. Sleeping Beauty -- 56. Codeine Can't Do It -- 57. A Shuddering Interaction -- 58. Double Indemnity -- 59. Breaking the Codeine -- 60. The Ultimate Ultram Primer I:  My Mood Is Better, But Boy Do I Hurt! -- 61. The Ultimate Ultram Primer II: I "Haight" Narcotics But I Hate Seizures Worse -- 62. The Ultimate Ultram Primer III:  Tremor-dol Trigger in Serotonin Syndrome -- 63. Too Much of A Good Thing -- Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications -- 64. Introduction -- 65. Pining For Pete In The Pain Clinic -- 66. You Do Not Look Well Today, Mon Ami -- 67. My Headache is Gone, But My Leg Now Hurts -- 68. Special 'K'ase -- 69. Not Manic About NSAIDs -- 70. Keep It Capped! -- 71. The ACE Is Not Always High -- 72. When The Smoke Clears, Relaxation Disappears -- 73. Befuddled by Aspirin -- 74. You Can't Trick Us! -- Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives -- 75. Introduction -- 76. The Worry That's Always With Us:  Now I'm Depressed -- 77. The Worry That's Always With Us: Tragic But Not Rare -- 78. Lack of Sedation -- 79. A Cold Isn't Going to Slow Me Down -- 80. Her Patients Never Wake Up On Time -- 81. When Enough Is Now Too Much -- 82. The Distressed Daughter -- 83. Check Check and Double Check -- 84. Doggone It-The Case is Cancelled -- 85. Noct' Out -- 86. Predisposed to Doze -- 87. Synergistic Sedation -- Part X. Drug-Drug Interactions Involving Neuromuscular Blockade Agents -- 88. Introduction -- 89. Blocked Again -- 90. Irreversibility Sux -- 91. Keep An "Ion" The Twitches -- 92. A Reversal of Misfortune -- 93. Stop Moving -- 94. There's Just Not Enough Roc In The World -- 95. Slow Sux I:  A Lengthy Wake-Up Period After Electroconvulsive Therapy -- 96. Slow Sux II:  I Remember Reviewing This For The Boards -- 97. Slow Sux III:  Where Did the Twitches Go? -- 98. Weakened All Weekend -- 99. The Patient Who Could Not Raise Her Head -- 100. An Unexpected Wait -- 101. Diabolical Cough Syrup -- Part XI. Drug-Drug Interactions Involving Antibiotics and Antifungals -- 102. Introduction -- 103. Full Stop -- 104. Flummoxed by the FLOX -- 105. Tales of Terror -- 106. Too Low To Go -- 107. A Fungal Story -- 108. Rejection Protection Turned Kidney Killer -- 109. Can't Get Well -- 110. Linezolid (I): Be VREy Careful -- 111. Linezolid (II):  Hyper and Hot -- 112. Not Sweet At All -- 113. Where Did All The Sugar Go? -- 114. Exposed! (Part 1) -- 115. Exposed! (Part 2) -- 116. Seizures on 5 West -- Part XII. Drug-Drug Interactions Involving Cardiovascular Medications -- 117. Introduction -- 118. Riding The Rollercoaster -- 119. A Pressing Need For Vasopressin! -- 120. Too Young To Die -- 121. A Widening Gyre -- 122. Misusing Mom's Meds -- 123. If the Patient Has No Renal Failure, Why is Her Potassium So High? -- 124. Prazosin and the PTSD Paratrooper -- 125. Nicardipine Notes -- 126. Hypotension Harry -- 127. Too Slow to Flow -- 128. Better Sleep But Slower Heart -- 129. Extreme Blood Pressure After Ephedrine:  Should We Rule Out Pheochromocytoma? -- 130. Heart-Stopping Treatment -- 131. Induction Crashes:  Are There Clues In the Ashes? -- 132. The Wakeup Call: 2AM Trauma -- 133.  Falling Down -- 134. A Hidden Drug -- 135. I'm Listening, I'm Listening -- 136. Jump Start My Heart -- 137. The Statin Trilogy (I): 'Statin' From The Beginning -- 138. The Statin Trilogy (II): Tripped And Fell At The Train 'Statin' -- 139. The Statin Trilogy (III): Welcome To The United 'Statins' Of America -- 140. Be Still, My Beating Heart -- 141. The Nice Niece -- 142. Cyclo Killer: Qu'est-ce que c'est? -- 143. Blurry-Eyed With Rapid Heart Beats -- Part XIII. Drug-Drug Interactions Involving Coagulation Modifiers -- 144. Introduction -- 145. Seize the Day -- 146. The Third and Final Complication -- 147. An Interaction With the Furniture -- 148. Macrolide Mishap for Little Miss Muffett -- 149. From Asymptomatic to Symptomatic:  a Cause of Nosebleed -- 150. The Consequences of Not Following A Cardiac Diet -- 151. Clopidogrel (I):  Bagel Brunch -- 152. Clopidogrel (II):  Conferring Over The Kung Pao -- Part XIV. Drug-Drug Interactions Involving Immunosuppressants, Antiemetics, and Chemotherapy -- 153. Introduction -- 154. Beaned -- 155. Addisonian Adjustment -- 156. Tea Time -- 157.  No Fits at Uffizi -- 158. Quit Steroids Quit Kidneys -- 159. The Fall Guy (I) -- 160. The Fall Guy (2) -- 161. The Topic of the Day -- 162. Bounce Back -- 163. Call The Cath Lab! -- 164. The Imatinib Inquiry:  A Theoretical Case (For Now) -- 165. A HAART-Breaking Tale -- Part XV. Drug-Drug Interactions Involving Neuropsychiatric Drugs -- 166. Introduction -- 167. Phenytoin (I): Going Crazy! -- 168. Phenytoin (II):  The Wrong Drug for the Schizophrenic -- 169. Dizzy and Depressed -- 170. The Funeral Is On Monday -- 171. This Antacid Is Making Me Sick! -- 172. Young at Heart -- 173. Shiver Yes, Die No -- 174. Clip and Dip -- 175. Blue Fog -- 176. Confiscated Contraceptives -- 177. Gotta Love Derm -- 178. Desperate for A Drink -- Part XVI. Drug-Drug Interactions Involving QT Prolonging DDIs -- 179. Introduction -- 180. Delusion At Heart -- 181. At Long Last -- 182. Metha-don't! -- 183. Flash Fire -- 184. I Am Dizzy When I Stand Up -- Part XVII. Drug-Drug Interactions Involving Foods and Nutrition -- 185. Introduction -- 186. High Fat Diet (I): No Juice For The Ketotic Kid -- 187. Protein Huffing and Puffing -- 188. Salty Sam -- 189. A Peak Potassium Problem -- 190. Awake? -- 191. Tropical Punch Packing a Real Knockout -- 192. When The Fire Won't Go Out -- 193. Peppermint Patty -- 194. From Bleeding Gums to Green Thumbs- A True Story -- 195. Delicious but Malicious -- 196. I Just Can't Lick This Problem -- 197.

Sommelier's Surprise -- 198. Dairy Carefully -- 199. Cold And Sick, Sick And Cold -- 200. TPN (I):  A Review and Two Interactions -- 201. TPN (II):  A Traumatic Case of Increased Metabolism -- 202. Skin and Bones -- 203. Enough to Make You Sick -- 204. Determined and Desperate to Diet -- Part XVIII. Drug-Drug Interactions Involving Spices and Supplements -- 205. Introduction -- 206. Caffeine Crash -- 207. Sad Sequelae -- 208. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Seizures -- 209. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar:  Sugar -- 210. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Subdural -- 211. "Khat" Unawares -- 212. Pain on the Plane -- 213. Ca va, c'est Kava -- 214. Summertime and the Herbals are Hot -- 215. Garlic I:  More Than Just Bad Breath -- 216. Garlic II:  A Girl Named Allicin -- 217. "Danshen" the Night Away -- 218. Caught Yellow-Handed -- 219. St. John:  Not Such A Saint -- 220. Hearing the News.