Part I. The best clinical cases in severe infections and sepsis -- Principles and management of sepsis -- Endocarditis in an HIV patient. Infection in an immunocompromised patient, the perfect costume in which to hide -- Intraabdominal sepsis. Portal and mesenteric vein thrombosis as first presentation of myeloproliferative disease in a young woman -- Skin or soft tissue sepsis. Necrotizing fasciitis -- Complicated intraabdominal sepsis. Fournier's gangrene secondary to perforated retrocaecal appendicitis: a turbulent and prolonged ICU admission -- Septic shock and complications. The use of venous-venous extracorporeal membrane oxygenation in a patient with severe acute respiratory distress syndrome and multiple organ failure due to septic shock -- Viral infections in the ICU -- HIV. Respiratory insufficiency in an HIV patient -- Herpesviridae. Severe varicella zoster virus reactivation after SARS-CoV-2 vaccination in an immunocompetent patient -- Herpesviridae. A young man with acute liver failure and hemolysis -- Influenza. Challenges in Infection Management in the Immunocompromised Patient -- SARS-CoV-2. Organizing pneumonia treated with high dose methylprednisolone in an adolescent with Covid-19 pneumonia under extracorporeal circulation -- Severe infections in the ICU -- Parasitic infections. Severe malaria in the ICU -- Parasitic infections. Dyspnea, oedema, and abdominal distention -- Mucormycosis. An unusual cause of intracranial hemorrhage: cerebral mucormycosis -- Fungal infections. A Case of Gastroparesis and Candidemia secondary to Gastric Ischemia -- Wrap-up -- Part II. The best clinical cases in respiratory medicine -- Principles and management of ARDS -- ARDS secondary to near-drowning. Drowning in seawater -- ARDS treatment in a patient with another condition. The use of inhaled nitric oxide for acute respiratory distress syndrome in a patient with a subarachnoid hemorrhage -- Post-partum ARDS. Postpartum ARDS in a Patient with Suspected Amniotic Fluid Embolism after Complicated Childbirth -- Airway complications. Management of a non-traumatic tracheal lesion in severe tracheobronchomalacia -- Bronchopleural fistula. Post COVID-19 bronchopleural fistula treated with "closed-lung" minimal ventilation and ECCO2R -- Weaning from mechanical ventilation. Antipsychotic-induced respiratory dyskinesia in a patient with severe SARS-CoV2 pneumonia -- Pulmonary embolism in the ICU -- Diagnosis of pulmonary embolism. An Uncommon Cause of Pulmonary Embolism -- Right ventricular failure in pulmonary embolism. The forgotten chamber: When in trouble, go back to basics -- Mechanical circulatory support in pulmonary embolism. VA-ECMO for resuscitation of cardiac arrest after pulmonary embolism in brain stem intracranial hemorrhage -- Wrap up -- Part III. The best clinical cases in cardiovascular medicine -- Principles and management of rhythm disturbances. Overview of cardiac arrest.-Arrhythmias. Electrical storm in a COVID-19 patient -- Antiarrhythmic drugs. A case of near-fatal chronic digoxin toxicity -- Cardiac arrest. Pediatric out-of-hospital cardiac arrest on the soccer pitch - how implementation of digital solutions into the chain of survival can help with a favorable outcome -- Principles and management of heart failure and cardiogenic shock -- Differential diagnosis of shock. A 60- year old woman with gastrointestinal bleeding in hemorrhagic shock- an unexpected shift in shock etiology -- Cardiogenic shock. Seizure-associated takotsubo cardiomyopathy complicated by cardiogenic shock and successfully treated with levosimendan -- Cardiogenic shock. Cardiogenic shock due to reversed Takotsubo syndrome associated with E-cigarrete or vaping product use-associated lung injury (EVALI) -- Ivabradine as an alternative to beta-blockade in Takotsubo cardiomyopathy: case report -- Myocarditis. Novel immunotherapy and mechanical cardiac support in myocarditis: A case report -- Peripartum cardiomyopathy. Peripartum cardiomyopathy- Diagnostic and therapeutic challenge -- Perioperative cardiovascular critical care. Impact of perioperative veno-arterial extracorporeal membrane oxygenation on outcome in a patient with impaired cardiac function undergoing open thoracoabdominal penetrating aortic ulcer repair -- Wrap-up -- Part IV. The best clinical cases in neurocritical care and severe trauma -- Principles and management of subarachnoid hemorrhage -- Respiratory complications of SAH. Systemic complications of subarachnoid hemorrhage -- Cardiovascular complications of SAH. Neurogenic stunned myocardium in subarachnoid hemorrhage -- Principles and management of severe trauma and bleeding -- Traumatic brain injury and rhabdomyolysis. Continuous renal replacement therapy management in a patient with severe traumatic brain injury and rhabdomyolysis-associated acute kidney injury -- Post-traumatic cardiac tamponade. Delayed post-traumatic tamponade: the end of the tunnel -- Pelvic trauma. Polytrauma patient with refractory shock -- Abdominal and pelvic bleeding control strategies. Resuscitative endovascular balloon occlusion of the aorta (REBOA) in a patient with exsanguinating penetrating torso trauma. A clinical case -- Principles and management of hemorrhagic shock -- Hemothorax. Massive Hemothorax Of Extremely Rare Cause -- Spleen rupture. An Unusual Cause of Syncope -- Transfusion complications. Blood transfusion triggered posterior reversible encephalopathy syndrome -- Wrap-up -- Part V. The best clinical cases in severe endocrine and metabolic disorders -- Endocrine and metabolic disorders in the ICU -- Diabetes ketoacidosis. New onset diabetes with diabetic ketoacidosis after SARS-CoV-2 infection in adult critically ill patient -- Porphyria. Acute Intermittent Porphyria: A challenging diagnosis and treatment -- Cyanide poisoning. Arterialization of venous blood -- Wrap-up -- Part VI. The best clinical cases in severe inflammatory disorders -- Inflammatory disorders in the ICU -- Systemic capillary leak syndrome. In case of severe hemoconcentration and hypovolemic shock, also think of zebras: a case of systemic capillary leak syndrome -- Haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis in a critically ill adult with asymptomatic post-acute COVID-19 -- Miastenia gravis. The approach to a patient with a myasthenic crisis in an intensive care unit -- Adult-onset Still's disease. A usual presentation of an unusual case -- Wrap-up.