Title:
RNAi technology
Author:
Gaur, Rajarshi Kumar.
ISBN:
9781439873250
Edition:
1st ed.
Publication Information:
Enfield, N.H. : CRC Press, 2011.
Physical Description:
xiv, 378 p. : ill. (some col.).
Contents:
1. Acute RNA interference for basic research and therapy / Federico Calegari -- 2. Deciphering post-transcriptional gene silencing pathways through genetic screens / Vincent Jauvion, Allison C. Mallory and Herv ̌Vaucheret -- 3. Implications of miRNA-directed gene silencing in cancer / Duncan Ayers -- 4. MicroRNA interference : concept and technologies / Zhiguo Wang and Xiaobin Luo -- 5. Silencing the disease messengers : progress and prospects in developing nucleic acid based therapeutics / Rakha H. Das and Nandini Verma -- 6. Artifical microRNA : a third generation RNAi technology / Pranjal Yadava -- 7. Pectin methylesterase enhances tomato bushy stunt virus P19 RNA silencing suppressor effects / Tatiana V. Komarova, Vitaly Citovsky and Yuri L. Dorokhov -- 8. MicroRNAs : a new paradigm for gene regulation / Luciana dos Reis Vasques, Clùdia Gasque Schoof and Eder Leite da Silva Botelho -- 9. A RNAi-based genome-wide screen to discover genes involved in resistance to tomato yellow leaf curl virus (TYLCV) in tomato / Henryk Czosnek ... [et al.] -- 10. RNAi for crop improvement / Imran Amin ... [et al.] -- 11. RNA silencing and viral encoded silencing suppressors / Masato Ikegami, Tatsuya Kon and Pradeep Sharma -- 12. Gene silencing and its applications in plants / S. Abdolhamid Angaj and Somayeh Darvishani -- 13. Use of RNAi technology for control of rice viruses / Indranil Dasgupta -- 14. Use of RNAi technology in medicinal plants / Pravej Alam ... [et al.] -- 15. RNA interference and wheat functional genomics / Pradeep Sharma and Rajender Singh -- 16. Biogenesis, processing and function of miRNA in plants and animals / Sakshi Issar and R.K. Gaur -- 17. RNA interference in fungi / B.M. Bashyal and Rashmi Aggarwal -- 18. Virulence of Fusarium spp. causing wilt disease of guava with special reference to RNAi / V.K. Gupta ... [et al.] -- 19. RNA interference : interactomics and therapeutics / Sayak Ganguli and Abhijit Datta.
Abstract:
"RNA interference (RNAi) is a system within living cells that helps to control active genes and their activity level. Two types of small RNA molecules--microRNA (miRNA) and small interfering RNA (siRNA)--are central to RNA interference. The discovery of RNAi was preceded first by observations of transcriptional inhibition by antisense RNA expressed in transgenic plants and more directly by reports of unexpected outcomes in experiments performed by plant scientists in the U.S. and The Netherlands in the early 1990s. RNAi technology are used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in microorganisms, plants and animals."--Provided by publisher.
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