Dedication -- Preface -- Acknowledgements -- Table of Contents -- Basic Premise -- Case 1. A "good" question -- Case 2. A "bad" question -- Case 3. Why were 116 patients excluded? -- Case 4. Sometimes a good question evolves from a bad one -- Case 5. What went wrong? -- Case 6. Check your facts -- Case 7. All is not lost -- Case 8. An important lesson -- Case 9. A lucky escape -- Case 10. A letter or a full paper -- Case 11. This could be serious. Be prepared -- Case 12. Not correct procedure -- Case 13. A lesson well learned -- Case 14. Taking out a patent. Should you or should you not? -- Case 15. Taking out a patent. Watch out -- Case 16. A laboratory lesson -- Case 17. Before you start any research -- Case 18. An offer of employment. What to look for -- Case 19. What should you do? -- Case 20. Who to trust -- Case 21. Elementary -- Case 22. Never give up -- Case 23. How long should a study go on? -- Case 24. What to do -- Case 25. To what journal should you send your work? -- Case 26. A drug sponsored trial -- Case 27. The difference between research and quality assurance/improvement -- Case 28. Stopping a clinical study -- Case 29. Controversy -- Case 30. The P Value -- Case 31. How many authors? -- Case 32. If you injure your patient -- Case 33. Multicenter trials -- Case 34. Unprofessional behavior -- Case 35. Tips on how to get the Institutional Review Board (IRB) submission completed and passed -- Case 36. How to perform and report the result of a survey -- Case 37. Validity of the cricoid pressure (Sellick's maneuver -- Case 38. Another unprofessional behavior -- Case 39. A data set -- Case 40. Taking over an ongoing clinical trial -- Case 41. Should you do a pilot study in this proposed trial? -- Case 42. An inconclusive result (negative result). What to do -- Case 43. Retrospective studies. What to watch out for -- Case 44. Plagiarism -- Case 45. Pediatric research -- Case 46. Your paper is rejected. What to do -- Case 47. You disagree with a conclusion of a published article -- Case 48.Is this a good study? -- Case 49. Meta-analysis of randomized controlled trials -- Case 50. Is the title of a paper or grant important? -- Case 51. Sampling and subjects -- Case 52. What not to do if you are a mentor -- Case 53. Be aware -- Case 54. A statistical impasse -- Case 55. A bad outcome -- Case 56. A case report -- Case 57. Are case reports becoming extinct -- Case 58. A clinical pharmacology study -- Case 59. Watch out -- Case 60. A new equipment -- Case 61. Those that ignore the past -- Case 62. What are the safety data for this formulation? -- Case 63. This is a test to see what you have learned -- Review of the clinical research process. From the beginning to the end -- The future of clinical research -- Summary of Pearls.