Preface: A New Disease? -- The Human Burden: Epidemiology of Diabetes across the World -- The Economic Burden: Direct and Indirect Costs of Diabetes -- The Global Burden of Diabetes -- The Ecological Approach to Self-Management in Diabetes -- Diabetes Outcomes and Social Determinants of Health -- Definition, Diagnostic Criteria, Screening, Diagnosis and Classification of Diabetes and Categories of Glucose Intolerance: an Update -- Homeostasis of Glucose and Intermediate Metabolism -- Pathophysiology of Type 1 Diabetes -- Pathophysiology of Type 2 Diabetes -- Genetic Determinants of Type 2 Diabetes -- Gene Expression Modifications in Type 2 Diabetes -- The Immune System and Inflammation in Type 2 Diabetes -- Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes -- Obesity in the Pathophysiology of Diabetes -- Pathogenesis of Gestational Diabetes -- Non-Alcoholic Fatty Liver in the Pathogenesis of Diabetes -- Microbiota in the Pathogenesis of Diabetes -- Diabetes and Circadian Rhythms -- Diabetes Management in Europe -- Diabetes Management in Asia -- Diabetes Management in the Americas -- Diabetes Management in the United States -- Diabetes Management in Mexico -- Diabetes Management in Africa -- Diabetes Management in Australia -- Evolution of the Patient-Centered Medical Home and Diabetes Care -- Outpatient Diabetes Management and the Chronic Care Model -- Clinical Practice Guidelines and Diabetes -- Evidence-Based Medicine and Diabetes: Contribution of Trials and Mega-Trials -- Measuring Diabetes Quality of Care: Clinical Outcomes, Cost-Effectiveness, and Patient Experience of Care -- Clinical Inertia and Diabetes Outcomes -- The Continuing Challenge of Patient Adherence -- Challenges and Scope of Diabetes Self-Care Education and Support -- Diabetes and Mental Health -- Tools of Self-Care: Self-Monitoring of Blood Glucose and Tele-Health Resources -- Continuous Glucose Monitoring in Clinical Practice: Ambulatory Glucose Profile and Advanced Glucose Sensing Technologies -- Type 2 Diabetes and Lifestyle Medicine -- Evidence and Implementation of Medical Nutrition Therapy in Persons with Diabetes -- Evidence and Implementation of Physical Activity and Exercise in Diabetes Management -- The "Old" Oral Antidiabetics -- Incretin Therapies: Current Use and Emerging Possibilities -- Sodium-Glucose Cotransporter 2 Inhibitors -- Use of Insulin in Outpatient Diabetes Management -- Insulin Pump Therapy -- Diabetes and Hypertension -- Diabetes and Atherogenic Dyslipidemia -- Obesity and Diabetes -- Metabolic and Bariatric Surgery in Diabetes Management -- Diabetes and Smoking: The Burden of Evidence -- Hyperglycemic Crises: Diabetic Ketoacidosis and Hyperosmolar Non-Ketotic Status -- Hypoglycemia: Diagnosis, Management and Prevention -- Inpatient Management of Diabetes and Hyperglycemia -- Diabetes and Infection -- Biochemical Mechanisms of Vascular Complications in Diabetes -- Diabetes and Cardiovascular Disease -- Diabetes and Stroke: The Role of Glucose Regulation -- Peripheral Arterial Disease and Diabetes Mellitus -- Ophthalmic Disease in Diabetes -- Diabetes and Oral Health -- Renal Disease in Diabetes -- Peripheral Diabetic Neuropathies -- Diabetic Cardiac Autonomic Neuropathy -- Autonomic Visceral Neuropathy and Gastrointestinal Disorders -- Urologic Complications of Diabetes -- Musculoskeletal Complications of Diabetes -- Diabetes and the Skin -- Foot Complications -- Diabetes and Cancer -- Diabetes in Children and Adolescents -- Pregnancy: Pregestational and Gestational Management -- The Elderly with Diabetes -- The Artificial Pancreas -- Stem-Cell Therapy -- Immune-Regulating Interventions -- Unproven Therapies for Diabetes -- Diabetes Prevention.