This book introduces basic concepts, principle, and methods of medical statistics systematically and practically, especially in the statistical design of the experiment in terms of the specific problems, adequate use of statistical methods based on actual data and the reasonable explanation for statistical results. This textbook combines statistical methods with the common application of SPSS software, which is flexible, convenient, and user-friendly; thus, students can focus on the deep understanding of statistics. The authors emphasize the application and generalization of statistical methods, and combine these methods with the modern statistical theory, such as sequential contingency table and multivariate statistical modelling, etc.