1. History of the premenstrual disorders. 2. The diagnosis of PMS/PMDD -- the current debate. 3. Premenstrual syndrome: a case of serotonergic dysfunction?. 4. Quantification of premenstrual syndrome and premenstrual dysphoric disorder. 5. Prevalence, impact on morbidity, and disease burden. 6. Comorbidity of premenstrual syndrome and premenstrual dysphoric disorder with other psychiatric conditions. 7. The clinical presentation and course of premenstrual symptoms. 8. Physiology of the menstrual cycle. 9. Neurotransmitter physiology: the basics for understanding premenstrual syndrome. 10. Pathophysiology I: role of ovarian steroids. 11. Pathophysiology II: neuroimaging, GABA, and the menstrual cycle. 12. Hormonal therapies overview. 13. The role of progesterone and GABA in PMS/PMDD. 14. The management of PMS/PMDD through ovarian cycle suppression. 15. Psychotropic therapies. 16. Complementary and alternative therapies. 17. Clinical evaluation and management. 18. Genetics of premenstrual dysphoric disorder. 19. Future directions in the pathophysiology of premenstrual dysphoric disorder: steps to future treatments.