chapter 1 Carbonic Anhydrases: Catalytic and Inhibition Mechanisms, Distribution and Physiological Roles / chapter 2 Acatalytic CAs: Carbonic Anhydrase-Related Proteins / chapter 3 Multiple Binding Modes Observed in X-Ray Structures of Carbonic Anhydrase Inhibitor Complexes and Other Systems: Consequences for Structure-Based Drug Design -- chapter 4 Development of Sulfonamide Carbonic Anhydrase Inhibitors / chapter 5 QSAR Studies of Sulfonamide Carbonic Anhydrase Inhibitors / chapter 6 Metal Complexes of Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors / chapter 7 Nonsulfonamide Carbonic Anhydrase Inhibitors / chapter 8 Clinical Applications of Carbonic Anhydrase Inhibitors in Ophthalmology / chapter 9 Cancer-Related Carbonic Anhydrase Isozymes and Their Inhibition / chapter 11 Carbonic Anhydrase Inhibitors in Dermatology / chapter 12 Carbonic Anhydrase Activators