Successful drug discovery. Volume 2

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Title:

Author:

Fischer, János, editor.

ISBN:

9783527800315

9783527800322

9783527800346

Physical Description:

1 online resource

Contents:

HDAC Inhibitor Anticancer Drug Discovery. From DMSO to the Anticancer Compound SAHA, an Unusual Intellectual Pathway for Drug Design / Ronald Breslow -- Romidepsin and the Zinc-Binding Thiol Family of Natural Product HDAC Inhibitors / A Ganesan -- The Discovery and Development of Belinostat / Paul W Finn, Einars Loza, Elisabeth Carstensen -- Discovery and Development of Farydak (NVP-LBH589, Panobinostat) as an Anticancer Drug / Peter Atadja, Lawrence Perez -- Discovery and Development of HDAC Subtype Selective Inhibitor Chidamide: Potential Immunomodulatory Activity Against Cancers / Xian-Ping Lu, Zhi-Qiang Ning, Zhi-Bin Li, De-Si Pan, Song Shan, Xia Guo, Hai-Xiang Cao, Jin-Di Yu, Qian-Jiao Yang -- Steroidal CYP17 Inhibitor Anticancer Drug Discovery. Abiraterone Acetate (Zytiga®): An Inhibitor of CYP17 as a Therapeutic for Castration-Resistant Prostate Cancer / Gabriel M Belfort, Boyd L Harrison, Gabriel Martinez Botella -- Anti-Infective Drug Discoveries. Discovery of Delamanid for the Treatment of Multidrug-Resistant Pulmonary Tuberculosis / Hidetsugu Tsubouchi, Hirofumi Sasaki, Hiroshi Ishikawa, Makoto Matsumoto -- Sofosbuvir: The Discovery of a Curative Therapy for the Treatment of Hepatitis C Virus / Michael J Sofia -- Central Nervous System(CNS) Drug Discovery. The Discovery of the Antidepressant Vortioxetine and the Research that Uncovered Its Potential to Treat the Cognitive Dysfunction Associated with Depression / Benny Bang-Andersen, Christina Kurre Olsen, Connie Sanchéz -- Antiulcer Drug Discovery. Discovery of Vonoprazan Fumarate (TAK-438) as a Novel, Potent and Long-Lasting Potassium-Competitive Acid Blocker / Haruyuki Nishida -- Cross-Therapeutic Drug Discovery (Respiratory Diseases/Anticancer). Discovery and Development of Nintedanib: A Novel Antiangiogenic and Antifibrotic Agent / Gerald J Roth, Rudolf Binder, Florian Colbatzky, Claudia Dallinger, Rozsa Schlenker-Herceg, Frank Hilberg, Lutz Wollin, John Park, Alexander Pautsch, Rolf Kaiser.

Abstract:

Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of the current drug development efforts. Backed by copious data and chemical information, the insight and experience of the contributors makes this one of the most useful training manuals that a junior medicinal chemist can hope to find and has won the support and endorsement of IUPAC.

Local Note:

John Wiley and Sons

Subject Term:

Drugs -- Design.

Pharmaceutical chemistry.

Drug Design

Chemistry, Pharmaceutical

Médicaments -- Conception.

Chimie pharmaceutique.

MEDICAL -- Pharmacology.

Drugs -- Design

Pharmaceutical chemistry