ch 1. The drug discovery and development process : a brief overview / Alex Matter -- ch 2. The drug discovery and development process : opportunities and challenges for MR techniques / Nicolau Beckmann and Markus Rudin -- Editorial comments -- ch 3. Imaging as biomarker for decision-making in drug development / Richard Hargreaves and John A. Wagner -- Editorial comments -- ch 4. Design of contrast agents for molecular imaging in vivo / Silvio Aime, Giovanni B. Giovenzana, Dario Longo, and Enzo Terreno -- Editorial comments -- ch 5. Rapid phenotyping of mice with MRI / X. Josette Chen and R. Mark Henkelman -- Editorial comments -- ch 6. Magnetic resonance imaging and spectroscopy in transgenic mice modeling Alzheimer's disease / Thomas Mueggler -- ch 7. Imaging Alzheimer's disease with MRI / Scott A. Small -- ch 8. MRI and MRS in animal models of focal cerebral ischemia / Markus Rudin, Peter R. Allegrini, and Martin Rausch -- ch 9. MRI in clinical studies of stroke / Eric Juettler, Jochen B. Fiebach, and Peter D. Schellinger -- Editorial comments -- ch 10. Pharmacologic magnetic resonance imaging (phMRI) / Bruce G. Jenkins, Ji-Kyung Choi, Joseph B. Mandeville, and Yin-Ching Iris Chen -- ch 11. Brain fMRI in clinical pharmacological studies / Irene Tracey, Petra Schweinhardt, and Chas Bountra -- ch 12. Imaging inflammatory processes of the brain : multiple sclerosis as an example / Martin Rausch, Iris-Katharina Penner, Cedric Berger, and Markus Rudin -- Editorial comments -- ch 13. Functional and molecular magnetic resonance imaging of preclinical cancer models in drug discovery and development / Zaver M. Bhujwalla, Kristine Glunde, Ellen Ackerstaff, Arvind P. Pathak, Barjor Gimi, Noriko Mori, Venu Raman, and Dmitri Artemov -- ch 14. MR for clinical pharmacological studies in cancer / Geoffrey S. Payne, David J. Collins, Elizabeth M. Charles-Edwards, Mounia Beloueche-Babari, and Martin O. Leach -- ch 15. Molecular imaging in cancer therapies of the future / Chrit Moonen --

Editorial comments -- ch 16. Cardiac MR techniques applied to small rodents / Matthias Nahrendorf and Wolfgang R. Bauer -- ch 17. Cardiac MRI techniques for clinical drug trials / Sebastian Kelle and Eike Nagel -- Editorial comments -- ch 18. Lung MRI in small rodents as a tool for the evaluation of drugs in models of airways diseases / Nicolau Beckmann, Yannick Crm̌illieux, Bruno Tigani, Harry Karmouty Quintana, Franȯis-Xavier Bl,̌ and John R. Fozard -- ch 19. Clinical applications of MRI in respiratory diseases / Christian Fink and Hans-Ulrich Kauczor -- Editorial comments -- ch 20. MR in preclinical diabetes and obesity drug discovery / Beat M. Jucker and Didier Laurent -- ch 21. MR in clinical diabetes research and drug trials / Michael Roden -- Editorial comments -- ch 22. Rheumatoid and osteoarthritis : preclinical applications of in vivo MR / Didier Laurent and Nicolau Beckmann -- ch 23. Rheumatoid and osteoarthritis : clinical applications / Manish Kothari and Charles Peterfy -- Editorial comments -- ch 24. In vivo magnetic resonance techniques in transplantation research / Nicolau Beckmann and Detlef Niese -- ch 25. MR imaging and the development of stem cell-based therapies / Piotr Walczak and Jeff W.M. Bulte -- Editorial comments -- ch 26. MRI in pharmaceutical safety assessment / David Reid -- ch 27. In vivo MR in pharmaceutical research : essential or nice to have? / Nicolau Beckmann and Jeffrey Evelhoch.