Preface -- Part I Novel Analytical Procedures for Signal Transduction -- 1 Phosphoproteomics-based Network Analysis of Cancer Cell Signaling Systems (Hiroko Kozuka-Hata and Masaaki Oyama) -- 2 Phos-tag-based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome (Eiji Kinoshita, Emiko Kinoshita-Kikuta, and Tohru Koike) -- 3 Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-based Biosensors (Kazuhiro Aoki) -- 4 Technology of Wheat Cell-free Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases (Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, and Tatsuya Sawasaki) -- Part II Mathematical Simulation of Signal Transduction -- 5 Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations (Daisuke Ohshima, Jun-ichiro Inoue, and Kazuhisa Ichikawa) -- 6 Stochastic Simulation of Stress Granules (Daisuke Ohshima, KyokoArimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, and Kazuhisa Ichikawa) -- 7 Temporal Coding of Insulin Signaling (Hiroyuki Kubota and Shinya Kuroda) -- Part III Structural Analysis of Signal Transduction -- 8 Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling (Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, and Ryuichiro Ishitani) -- 9 Structural Basis for the Signal Initiation by TNF and TNFR (Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, and Yuriko Yamagata) -- 10 Regulation of NF-κB Pathway by Linkage-specific Ubiquitin-binding Domains (Yusuke Sato) -- Part IV Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation -- 11 NF-κB Signaling and Lymphoid Malignancies (Shoji Yamaoka) -- 12 Ubiquitination-mediated NF-κB Regulation in Inflammatory Response (Fuminori Tokunaga) -- 13 NF-κB Signaling in Osteoclastogenesis (Yuu Taguchi, Jin Gohda, and Jun-ichiro Inoue) -- 14 Mitogen-activated Protein Kinase Signaling and Cancer (Mutsuhiro Takekawa and Yuji Kubota) -- 15 Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression (Atsushi Enomoto, Liang Weng, and Masahide Takahashi) -- 16 Protein Modifications Pace the Circadian Oscillation of Biological Clocks (Hikari Yoshitane and Yoshitaka Fukada) -- 17 Keap1-Nrf2 Regulatory System and Cancer (Keiko Taguchi and Masayuki Yamamoto) -- 18 Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction (Takeshi Endo and Kazunori Takano) -- 19 Molecular Signaling and its Pathogenic Alterations in Neuromuscular Junction Formation and Maintenance (Ryo Ueta and Yuji Yamanashi) -- 20 Post-translational Modification of Tcf/Lef: New Insights into the Regulation of Wnt/β-catenin Signaling (Tohru Ishitani) -- BM Index.