1. Introduction / Rong (Ron) Liu -- 2. Solubility theories / Steven H. Neau -- 3. Prediction of solubility / Yisheng Chen, Xiaohong Qi, and Rong (Ron) Liu -- 4. Preformulation aspects of insoluble compounds / Wei-Qin (Tony) Tong and Hong Wen -- 5. Water-insoluble drugs and their pharmacokinetic behaviors / Honghui Zhou -- 6. Regulatory aspects of dissolution for low solubility drug products / Pradeep Sathe ...[et al.] -- 7. Formulation strategies and practice used for drug candidates with water-insoluble properties for toxicology, biology, and pharmacology studies in discovery support / Lian-Feng Huang ... [et al.] -- 8. Applications of complexation in the formulation of insoluble compounds / Wei-Qin (Tony) Tong and Hong Wen -- 9. Solubilization using cosolvent approach / Jay S. Trivedi -- 10. Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery: pt. 1. Parenteral aplications / John B. Cannon, Yi Shi, and Pramod Gupta -- 11. Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery: pt. 2. Oral applications / John B. Cannon and Michelle A. Long --

12. Micellization and drug solubility enhancement / Rong (Ron) Liu, Rose-Marie Dannenfelser, and Shoufeng Li -- 13. Micellization and drug solubility enhancement: pt. 2. Polymeric micelles / Rong (Ron) Liu, M. Laird Forrest, and Glen S. Kwon -- 14. Liposomes in solubilization / Rong (Ron) Liu, John B. Cannon, and Sophia Y.L. Paspal -- 15. Pharmaceutical salts / Steven H. Neau -- 16. Prodrugs for improved aqueous solubility / Steven H. Neau -- 17. Particle size reduction / Robert W. Lee ... [et al.] -- 18. Development of solid dispersion for poorly water-soluble drugs / Madhav Vasanthavada, Wei-Qin (Tony) Tong, and Abu T.M. Serajuddin -- 19. Alteration of the solid state of the drug substances: polymorphs, solvates, and amorphous forms / Paul B. Myrdal and Michael J. Jozwiakowski -- 20. Pharmaceutical powder technology - building the pyramid of knowledge and the challenge of FDA's PAT initiative / Hans Leuenberger, Silvia Kocova El-Arini, and Gabriele Betz -- 21. Soft gelatin capsules development / S. Esmail Tabibi and Shanker L. Gupta -- 22. Oral modified-release drug delivery for water-insoluble drugs / Shaoling Li, Nuo (Nolan) Wang, and Rong (Ron) Liu -- 23. Scalable manufacturing of water-insoluble drug products / Nitin P. Pathak and Richard (Ruey-ching) Hwang.