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Cover image for Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets
Title:
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets
Author:
Boelsterli, Urs A., 1948-
ISBN:
9780849372728
Edition:
2nd ed.
Publication Information:
Boca Raton : CRC Press, 2007.
Physical Description:
399 s.
Contents:
Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.
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Book 7.2/12/399511 QV 602 B671 2007
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