The biology and genetics of cells and organisms -- The nature of cancer -- Tumor viruses -- Cellular oncogenes -- Growth factors and their receptors -- Cytoplasmic signaling circuitry programs many of the traits of cancer -- Tumor suppressor genes -- pRb and control of the cell cycle clock -- p53 and apoptosis: master guardian and executioner -- Eternal life: cell immortalization and tumorigenesis -- Multistep tumorigenesis -- Maintenance of genomic integrity and the development of cancer -- Dialogue replaces monologue: heterotypic interactions and the biology of angiogenesis -- Moving out: invasion and metastasis -- Crowd control: tumor immunology and immunotherapy -- The rational treatment of cancer.