Why : biology by the numbers -- What and where : construction plans for cells and organisms -- When : stopwatches at many scales -- Who : "bless the little beasties" -- Mechanical and chemical equilibrium in the living cell -- Entropy rules! -- Two-state systems : from ion channels to cooperative binding -- Random walks and the structure of macromolecules -- Electrostatics for salty solutions -- Beam theory : architecture for cells and skeletons -- Biological membranes : life in two dimensions -- The mathematics of water -- A statistical view of biological dynamics -- Life in crowded and disordered environments -- Rate equations and dynamics in the cell -- Dynamics of molecular motors -- Biological electricity and the Hodgkin-Huxley model -- Light and life -- Organization of biological networks -- Biological patterns : order in space and time -- Sequences, specificity, and evolution -- Whither physical biology?