Normal Stem Cell: Entity or State? -- Normal Stem Cells: Biology, Collection/Harvesting, and Ex Vivo Manipulations -- A Concept of Cancer Stem Cells: Entity and Theories -- Cancer Stem Cell Markers: Classification and Their Significance in Cancer Stem Cells -- Epigenetic Mechanisms Involved in Cancer Stem Cell Profiles -- Mitochondrial Respiration of Cancer Stem Cells -- Metabolism in Cancer Stem Cells -- Different Approaches for Anticancer/Antitumor Therapy -- Targeted Cancer Stem Cell Therapy -- Bioengineered CSC Tumors -- Summary on the Role of Bioengineering in the Cancer Stem Cell Paradigm.