Part I: Modeling & Simulation Fundamentals -- Introduction to Modeling & Simulation -- The Modeling & Simulation Lifecycle Process -- Fidelity, Resolution, Accuracy and Uncertainty -- Conceptual Modeling -- Types of Models -- Model Verification & Validation -- Part II: Methods and Methodologies -- Modeling the Environment -- Modeling Behavior -- Modeling Time -- Discrete Event Simulation -- Continuous Time Simulation -- Agent Based Simulation -- System Dynamics Simulation -- Hardware-in-the-Loop Simulation -- Human-in-the-Loop Simulation -- Part III: Experimentation, Execution & Results -- Design of Experiments -- Surrogate Modeling -- Monte Carlo Analysis -- Wargames -- Distributed Simulation & Architectures -- Part IV: Introduction to Systems Engineering -- Systems Engineering Fundamentals -- Introduction to Systems Thinking -- Model Based Systems Engineering -- Part V: M&S in Systems Engineering Life Cycle -- Real-time Data Driven Arterial Simulation for Performance Measure Estimation -- Rotorcraft Pilot's Associate -- Framework Assessing Cost and Technology -- Model Based Systems Engineering: Extracorporeal Membrane Oxygenation (ECMO) Therapy -- Computational Modeling of Complex Enterprise Systems: A Multi-Level Approach -- Real Time Simulation of a Nuclear Power Plant with Embedded Hardware -- Return on Investment Metrics for Funding Modeling and Simulation.