Preface -- Laser physics and laser sources for cardiovascular applications -- Optic fibers and mechanical properties of laser catheters -- Landmarks along the introduction of laser to cardiovascular therapy -- Laser-thrombus interaction: from basic research to clinical utilization in the management of cardiovascular diseases -- Laser for treatment of acute coronary syndromes -- Laser for management of ST-elevation acute myocardial infarction -- Laser for revascularization of complex targets: old SVGs, CTO, left main disease, stent restenosis -- Laser utilization for synergistic technology strategy for coronary revascularization: laser and directional rotablation; laser combined with drug eluting balloon -- Laser for revascularization of  peripheral arterial disease- SFA, renal, subclavian, carotid arteries -- Laser for infra-popliteal revasculariztion -- TMR- physiology, pathology and basic research concepts -- TMR-endovascular and surgical techniques and clinical outcomes -- Laser applicationfor venous thrombosis -- Laser for IVC filter removal -- Laser for interventional electrophysiology - extraction and removal of pacemaker and AICD leads -- Laser for treatment of cardiac arrhythmias -- Laser application for treatment of congenital heart disease -- Nursing perspectives of cardiovascular laser procedures -- Laser safety in the cardiovascular suite and  the operation room -- Laser induced cardiovascular complications : mechanisms, recognition and management -- Laser in cardiovascular veterinary medicine.