Introduction -- Oncogene Addiction in Solid Tumors -- Pharmacology and Clinical Development of New Molecularly Targeted Agents -- Biomarkers as Prognostic, Predictive and Surrogate Endpoints -- Evaluation of Response in Malignant Tumors Treated with Targeted Agents -- Targeted Therapies for HER2-Positive Breast Cancer -- Role of PARP Inhibitors in Triple Negative Breast Cancer (TNBC) -- Targeted Therapies in Squamous Cell Carcinoma of the Head and Neck -- Targeted Therapies for NSCLC -- Targeted Therapies for Gastric Cancer -- Targeted Therapies for Pancreatic Cancer -- Targeted Therapies in Hepatocellular Carcinoma -- Targeted Therapies for Colorectal Cancer -- Targeted Therapy in Gastrointestinal Stromal Tumors -- Targeted Therapies in Kidney Cancer -- Targeted Therapies in Melanoma -- Targeted Therapies for Prostate Cancer -- Targeted Therapies for Bone Metastases.