What is "focal therapy" of PCa and why should we offer it ? -- Natural development of PCa under special consideration of histopathological pattern -- Imaging and - targeted biopsies as a basic prerequisite or focal therapy -- Surveillance vs focal therapy: Pro & Con -- Focal hemiablation and focal salvage -- Multifocal therapies in PCa (Tookad, Sonablate, Electroporation) -- Focal Brachytherapy -- Focal Cryotherapy -- Potential diagnostic and therapeutic technologies: Trim probe Protonterapy, Cyberknife, Electroporation -- Status quo 2013 -- History of  HIFU from prototypes to "Focal.One".