1. Acute Kidney Injury (AKI): Definitions and clinical context (Z. Ricci) -- 2. Epidemiology of AKI (E. Hoste) -- 3. Pathophysiology of AKI: Ischemia/reperfusion, Sepsis/inflammation, Toxicity, Vascular (A.B.J. Groeneveld,) -- 4. Diagnostic work-up of the patient with suspected AKI: Oliguria, Metabolic acidosis (J. Prowle) -- 5. Uremic toxins (R. Vanholder) -- 6. The kidney and other organs/conditions: Heart, Cardiorenal syndromes, Uremic pericarditis, Lungs/Asthma renale, Liver/Hepatorenal syndrome, Gut/Uremic mucositis/GI permeability, Brain, Coagulation, Pregnancy (S. Bagshaw) -- 7. Biomarkers for AKI (M. Ostermann) -- 8. Prevention of AKI and protection of the kidney: Fluids, Vasopressors, Inotropes and vasodilators, Anti-inflammatory treatment, Antioxidants; Prevention of contrast associate nephropathy (M. Joannidis, co-authors ICM paper) -- 9. Timing of renal replacement therapy (RRT) in AKI (S. Bagshaw,) -- 10. Dosing of RRT (C.S.C. Bouman) -- 11. Types of RRT: Continuous vs. intermittent, Convection vs. diffusion, Predilution vs. Postdilution, SLED, Replacement fluids, Membranes, Biocompatability (L.G. Forni) -- 12. Anticoagulation for RRT: Heparin, Citrate, HIT (H.M. Oudemans) -- 13. Metabolic aspects of continuous renal replacement therapy (CRRT): Control of acidosis, Control of electrolytes, Bioenergetic gain and loss, Loss of (micro)nutrient, Nutrition (O. Joannes Boyeau) -- 14. CRRT: in sepsis, after cardiac surgery (P. Honore) -- 15. CRRT in the pediatric population (Z. Ricci) -- 16. Drug removal by CRRT and drug dosing in the patient on CRRT (M. Schetz) -- 17. CRRT for intoxications (D. Cruz) -- 18. How to avoid harm in the patient with AKI: summary of key points of previous chapters (H.M. Oudemans) -- 19. Follow-up and long-term renal outcomes of patients surviving AKI (J. Prowle).