Part 1: Epidemiology and Biology Epidemiology of Kidney Cancer -- Pathological Classification -- Molecular Biology of Kidney Cancer --  Biomarkers for Kidney Cancer -- Genetic Heterogeneity of Kidney Cancer -- Metabolic Basis of Kidney Cancer. Part 2: Clinical Considerations Clinical Presentation and Staging.-  Hereditary Kidney Cancer.  Part 3: Surgical and Local Control Modalities Surgical Approaches to Early Stage Kidney Cancer -- Cytoreductive Nephrectomy -- Metastasectomy -- Energy Ablative Techniques in Kidney Cancer -- The Role of Radiation Therapy in Kidney Cancer. Part 4: Systemic Therapy Considerations Adjuvant Systemic Therapy -- Cytokines and Vaccine Therapy -- PD1 and PDL1 Targeted Therapy -- Angiogenesis Inhibitor Therapy -- The Role of mTOR inhibitors and PI3K Pathway Blockade -- Sequential versus Combination Strategies -- Presurgical Therapy in Kidney Cancer -- Toxicity Management for Patients on Targeted Therapies -- Emerging Agents in Kidney Cancer.