Introduction -- Anatomy of the penis, with special attention to the tunica albuginea and the corpora cavernosa -- Epidemiology -- Etiology and risk factors -- Nosology -- Natural history -- Experimental models and laboratory research -- Symptoms, their physiopathology, and outpatient clinical practice and diagnosis -- Congenital and acquired penile curvature: relationships and differences -- Psychological aspects of Peyronie's disease -- Imaging -- Therapy: a general approach -- Medical therapy -- Combination therapy -- Surgical therapy: Why and when? An overview -- Advanced techniques of plication surgery with basal approach: Why and when? -- Corporoplasty: Why and when? -- Plaque surgery: Why and when? -- Surgical techniques for difficult and complicated cases.- Future perspectives.  .