Historical background and epidemiology -- Radiological diagnosis -- Nuclear medicine diagnosis -- Endocrinological approach to diagnosis -- Cytological diagnosis -- Classification -- Immunohistochemical approach to diagnosis -- Insulinoma -- Glucagonoma -- Somatostatinoma -- VIPoma -- Gastrinoma -- ACTH-producing tumor -- Serotonin-producing tumor -- GRF-, GH-, Ghrelin- and PTH-producing tumor -- Nonfunctioning pancreatic neuroendocrine neoplasms including PP-, calcitonin- and neurotensin-producing tumors -- Poorly differentiated neuroendocrine carcinoma of the pancreas -- Mixed adenoneuroendocrine carcinoma of the pancreas -- Hyperplastic and dysplastic pancreatic neuroendocrine lesions -- Molecular pathology -- Surgical therapy -- Pharmacological therapy.