Evaluation and Diagnosis -- Leukocoria: Differential Diagnosis -- Staging and Grouping -- Epidemiologic Aspects -- International Perspective -- Tumorigenesis -- Retinocytoma or Retinoma -- Genetic Counseling and Testing -- Treatment Options -- Focal Therapy -- Intravenous Chemotherapy -- Intra-Arterial Chemotherapy -- Intravitreal Chemotherapy -- Teletherapy -- Enucleaton -- Histopathologic Features and Risk Factors -- Orbital Retinoblastoma -- Metastatic Disease -- Non Ocular Tumors -- Trilateral Retinoblastoma -- Children's Oncology Group (COG) Trials for Retinoblastoma.