Overview of Sickle Cell Disease -- Laboratory Tests Used in Diagnosis and Monitoring of Sickle Cell Disease -- Organization of Care for Sickle Cell Disease -- Overview and general principles -- Pain in Sickle Cell Disease -- Respiratory and Cardiac Complications in Sickle Cell Disease -- Neurological Complications of Sickle Cell Disease -- Renal and Urological Complications in Sickle Cell Disease -- Bone and Joint Complications in Sickle Cell Disease -- Ophthalmological complications in Sickle Cell Disease -- The Spleen in Sickle Cell Disease -- Infection and Infection Prophylaxis in Sickle Cell Disease -- Gastroenterological Complications in Sickle Cell Disease -- Anemia and Sickle Cell Disease -- Leg Ulceration in Sickle Cell Disease -- Management of Pregnancy in Sickle Cell Disease -- Surgical Management of Patients with Sickle Cell Disease -- Sickle Cell Disease Treatment Modalities -- Out-Patient Management of Sickle Cell Disease Patients.