Introduction -- Syndrome-specific Anatomy and Physiology -- Earth-bound Pathophysiology of Increased Intracranial Pressure -- Pathophysiology of Increased Intracranial Pressure in Weightlessness -- Pathology, demographics and anatomy of papilledema -- Microgravity Induced Cephalad Fluid Shift -- The Role of Carbon Dioxide -- Advanced Resistive Exercise Device (ARED) -- Diet on board the International Space Station.