The Statement of the Problem -- Dentine Physiology: A Key to the Understanding of the Problem -- The Prevalence of Dentine Hypersensitivity -- Aetiology and Clinical Features of Dentine Hypersensitivity -- Advances in the Diagnosis of Dentine Hypersensitivity -- Advances in In Vitro Testing Techniques for Dentine Hypersensitivity -- From Concept to Production: An Overview of the Development of Desensitizing Agents -- The Relevance of In Vivo Evaluation of Desensitizing Agents for Managing Dentine Hypersensitivity -- Novel Clinical Approaches for the Treatment of Dentine Hypersensitivity -- The Impact of Dentine Hypersensitivity on the Quality of Life -- Advances in the Management of the Patient with Dentine Hypersensitivity: Motivation and Prevention -- Future Strategies for the Development of Desensitising Products.