Historical perspective of Raynaud's phenomenon -- definition, nomenclature and diagnostic criteria -- Epidemiology of Raynaud's Phenomenon -- Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular System -- Pathophysiological Regulation of the Cutaneous Vascular System in Raynaud's Phenomenon -- Primary Raynaud's Phenomenon -- Raynaud Phenomenon In The Pediatric Age.-Secondary Raynaud's phenomenon -- Traumatic Vasospastic Disease -- Other Secondary Causes -- Raynaud's Mimics -- Nailfold Capillaries.-Non-Invasive methods of assessing Raynaud's phenomenon -- Angiography -- Autoantibodies in Raynaud's Phenomenon -- Systemic Vasospasm -- Clinical Outcome Measures in Raynaud's Phenomenon -- Design and reporting of randomised controlled trials for Raynaud's phenomenon -- Non-drug Approaches to Treating Raynaud's Phenomenon -- Drug Treatment of Raynaud's Phenomenon -- Management of digital ischemia -- Surgical Management -- Practical Approaches to Treatment: Case Studies.