THE SKIN -- The Skin Structure And Penetration Pathways Through The Skin -- The Increasing Importance Of The Follicular Route In Dermal And Transdermal Drug Delivery -- The Importance Of SC Lipid Organization For Skin Barrier Function -- Nanostructure Of The Epidermal Extracellular Space Investigated By Cryo-Electron Microscopy And Tomography -- The Correlation Between Transepidermal Water Loss And Percutaneous Drug Absorption -- Influence Of Excipients  On The Stratum Corneum Lipids And Epidermal Tight Junctions --  PENETRATION ENHANCEMENT TECHNIQUES IN SKIN DELIVERY -- Classification Of Penetration Enhancement Techniques -- DRUG MANIPULATION STRATEGIES IN PENETRATION ENHANCEMENT -- Selection Of A Proper Prodrug For Penetration Enhancement -- Supersaturated Solutions For Penetration Enhancement -- Eutectic Systems For Penetration Enhancement -- INFLUENCE OF VEHICLE EFFECTS IN PENETRATION ENHANCEMENT -- Dermal and Transdermal Formulations -- EMULSIONS (AS SKIN DELIVERY SYSTEMS) AS VEHICLES FOR SKIN DELIVERY.- GELS AS VEHICLES FOR SKIN DELIVERY.