Basic principles: Femtosecond Laser for Advanced Single-Step Corneal Refractive Surgery: Basic knowledge of Physics and Optics -- Wound Healing after Femtosecond Laser Corneal Refractive Surgery -- Corneal Nerve and Keratocyte Response to Relex Surgery. Clinical Development and Current Techniques: Brief Historical Overview of the Clinical Development of Relex Surgical Procedure -- Current Technique and Instrumentation for SMILE -- Refining Results with SMILE: Tips & Tricks -- Overview of Clinical Results for Low and Mid Myopia -- Astigmatism Correction -- Clinical Results in High Myopia -- Complications after SMILE and its Management Including Re-Treatment Techniques -- Management of Laser Settings for Better SMILE Surgery -- Advantages and Disadvantages of Different Cap Thicknesses. Clinical Science Related to SMILE: The Key Characteristics of Corneal Refractive Surgery: Biomechanics, Corneal Sensation, Spherical Aberration and Contrast Sensitivity after SMILE -- Centration in ReLEx Surgery -- How to Improve the Refractive Predictability -- Transmission and Scanning Electron Microscopy of the Extracted Lenticules -- Collagen Characteristics & Refractive Outcomes. Future Concepts: SMILE for Very High Myopia -- Hyperopic Correction by ReLEx -- Concept of Reversible Corneal Refractive Surgery (Lenticule Re-Implantation). Marketing & Patient Communication: Marketing of SMILE.