Mechanisms of Thrombolysis -- The Ischemic Penumbra and Cell Survival -- The March of Thrombolytic Therapy for Acute Ischemic Stroke to Clinical Trials: Pre-Clinical Thrombolysis and Adjuncts to Thrombolysis Research -- Combination of Thrombolytic Therapy with Antithrombotics and Neuroprotectants -- Pilot and Preliminary Studies of Thrombolytic Therapy for Stroke -- Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large, Randomized Clinical Trials -- Intra-Arterial Thrombolysis in Acute Ischemic Stroke -- Mechanical Revascularization with Embolectomy Devices -- Combinations of Intravenous t-PA and Endovascular Therapy -- Thrombolytic Therapy for Acute Stroke and the Test of Time -- How to Run an Effective Code Stroke -- Telestroke: Delivery and Design -- The Impact of Neuroimaging on Acute Stroke Treatment: Role of Magnetic Resonance Imaging -- The rt-PA for Acute Stroke Protocol.