Chapter. 1. Autonomous Intelligent Cyber-defense Agent: Introduction and Overview -- Chapter. 2. Alternative Architectural Approaches -- Chapter. 3. Perception of Environment -- Chapter. 4. Perception of Cyber Threats -- Chapter. 5. Situational Understanding and Diagnostics -- Chapter. 6. Learning about the Adversary -- Chapter. 7. Response Planning -- Chapter. 8. Recovery Planning -- Chapter. 9. Strategic Cyber Camouflage -- Chapter. 10. Adaptivity & Antifragility -- Chapter. 11. Negotiation and Collaboration -- Chapter. 12. Human Interactions -- Chapter. 13. Testing and Measurements -- Chapter. 14. Deployment and Operation -- Chapter. 15. Command in AICA-intensive Operations -- Chapter. 16. Risk Management -- Chapter. 17. Policy Issues -- Chapter. 18. Development Challenges -- Chapter. 19. Case Study A: A Prototype Autonomous Intelligent Cyber-defense Agent -- Chapter. 20. Case Study B: AI Agents for Tactical Edge -- Chapter. 21. Case Study C: the Sentinel Agents.