Introduction -- Part I: Overview -- Genotype, Phenotype and Environment -- Regulation and Control -- Evolution -- Origins of Life and Earth Prehistory -- Part II: Information -- The Nature of Information -- The Transmission of Information -- Sets and Combinatorics -- Probability and Likelihood -- Statistics and Causation -- Randomness and Complexity -- Systems and Networks -- Useful Algorithms -- Part III: Biology -- The Nature of Living Things -- The Molecules of Life -- Environment and Ecology -- Part IV: Omics -- Genomics -- Transcriptomics and Proteomics -- Microbiomics -- Viruses -- Single Cell Analysis and Multiomics -- Biological Signaling -- Regulatory Networks -- The Nervous System -- Phenomics -- Part V: Applications -- Medicine and Disease -- Drug Discovery -- Forensic investigation -- Pandemics -- Domestication -- The Organization of Knowledge.