FOUNDATIONS -- Institutional Governance of Responsible Research and Innovation -- The ETHNA System and Support Tools -- Importance and Necessity of Stakeholder Engagement -- EXPERIENCES AND LESSONS LEARNED -- Evaluation of RRI Institutionalisation Endeavours: Specificities, Drivers, Barriers, and Good Practices based on a Multi-Stakeholder Consultation and Living Lab Experiences. -Implementing RRI in a Non-Governmental Research Institute -- Implementing RRI in a Research and Innovation Ecosystem -- Developing RRI and Research Ethics at University -- ETHICAL TOOLS INTO PRACTICE -- Relevance and Challenges of Ethics Committees -- Responsible Research & Innovation Learning Facilitation -- Activities to Foster Public Engagement in Research and Innovation. Examples from the NewHoRRIzon Project -- LOOKING INTO THE FUTURE: MAIN CHALLENGES -- Gender mainstreaming in RRI: The Double Challenge -- Navigating the Future and Overcoming Challenges to Unlock Open Science -- Ethics and Development of Advanced Technology Systems in Public Administration.