Section I: Anatomy, physiology, and general principles -- Anterior skull base anatomy -- Lateral skull base anatomy -- CSF physiology -- Diagnosis of CSF leak -- Imaging for detection of CSF leaks -- Conservative and medical therapy for CSF leaks -- CSF division -- Anesthesia considerations in skull base reconstruction -- Allografts in skull base reconstruction -- Section II: Anterior skull base pathology -- Traumatic and iatrogenic CSF leaks -- Congenital encephaloceles -- Anterior skull base surgical approaches -- Section III: Lateral skull base surgical approaches -- Traumatic and iatrogenic CSF leaks -- Spontaneous CSF leaks and encephaloceles -- Lateral skull base surgical approaches -- Section IV: Anterior skull base reconstruction -- Free graft techniques -- Local vascularized pedicled flaps -- Extracranial flaps -- Microvascular reconstruction -- Reconstruction of the frontal and ethmoid defects -- Reconstruction of sphenoid defects: lateral recess, sellar, tuberculum, andplanum defects -- Reconstruction of the clival and craniocervical junction defects -- Section V: Lateral skull base reconstruction -- Management of CSF leaks during otologic surgery -- General repair principles following posterior cranial base surgery -- Reconstruction of the middle cranial fossa floor -- Reconstruction of large temporal bone defects -- Section VI: Postoperative care -- Post operative management following skull base reconstruction -- Management of the postoperative leak -- Other complications following skull base reconstruction -- Outcomes of anterior skull base reconstruction -- Outcomes of lateral skull base reconstruction -- Medicolegal issues in skull base reconstruction. Section VII: Future applications -- Emerging developments in skull base reconstruction.