Introduction to Clinical Research Informatics -- From Notations to Data: The Digital Transformation of Clinical Research -- Methodological Foundations of Clinical Research -- The Clinical Research Environment -- Biorepositories -- Study Protocol Representation -- Clinical Research Information Systems -- Public Policy Issues in Clinical Research Informatics -- Integrating EHR and Research -- Data Quality in Clinical Research -- Research Data Governance, Roles, and Infrastructure -- Informatics Approaches to Patient Recruitment -- Patient Registries for Clinical Research -- Managing clinical data/research data and phenotyping/cohort discovery -- Patient Reported Outcome Data -- Laboratory Data [New] -- Molecular, Genetic and other -omic Data -- Data Sharing: Clinical Trials Registries, Results Databases, and Research Data Repositories -- Knowledge Representation and Ontologies -- Developing and Promoting Data Standards for Clinical Research -- Non-Hypothesis Driven Research: Data mining and knowledge Discovery -- Advancing Clinical Research through Natural Language Processing on Electronic Health Records: Traditional Machine Learning Meets Deep Learning -- Back to the Future: The Evolution of Pharmacovigilance in the Age of Digital Healthcare -- The Evolving Role of Consumers -- Research in Open Environments -- Research in Context of Learning Health Systems.