Section 1: General issues -- 1. The impact of ageing on pharmacokinetics -- 2. Polypharmacy: Definition, Epidemiology, Consequences and Solutions -- 3. Drug-Drug and Drug-Nutrients Interactions: From Theory to Clinical Relevance -- 4. Inappropriate Prescription of Medicines -- 5. Prescribing Cascades -- 6. Adverse Drug Reactions in Older People: a 21st Century View -- 7. Adherence: How to Measure and Improve It -- 8. Medication reconciliation and review: theory, practice and evidence -- 9. The role of pharmacists in optimizing drug therapy -- 10. Deprescribing: Evidence base and implementation -- Section 2: Geriatric syndromes and common chronic conditions -- 11. General principles of management of patients with multimorbidity and frailty -- 12. Frailty and Drug Therapy -- 13. Falls and Impaired mobility -- 14. Delirium -- 15. Incontinence -- 16. Constipation -- 17. Pain -- 18. Hypertension -- 19. Heart Failure -- 20. Pharmacological treatment of cognitive and behavioral disorders in dementia -- 21. Pharmacological treatment of osteoporosis in older patients -- 22. Chronic respiratory disease: COPD, IPF -- 23. Diabetes -- 24. Stroke therapeutics in the care of older persons -- 25. Optimizing pharmacotherapy in older patients with depression or anxiety -- 26. Nutritional Deficiency and Malnutrition -- 27. Pharmacotherapy of Insomnia in older adults -- 28. Chronic kidney disease -- 29. Palliation at End of Life.