Anatomy and Physiology -- The four layers of meninges -- The BBB -- The cerebrospinal fluid (CSF) and the Interstitial fluid (ISF) -- Introduction to liquorpheresis -- Clearing the CSF as a therapeutic strategy in neurodegenerative diseases -- Definitions of procedures, including a historical perspective -- Systems and procedures -- Types of procedures and systems -- Classification and definitions of the different types of procedures for mechanical filtration of the CSF -- The mechanism of action -- The regime of usage -- The implantability -- The power for CSF flow -- The CSF filtrating or neutralizing method -- Applications and industry -- Multiple sclerosis, autoimmune encephalitis, and polyradiculomyelitis -- Meningeal carcinomatosis and leptomeningeal metastases -- Infectious diseases -- Viral encephalitis and viral myelitis -- Bacterial meningoencephalitis -- Fungal meningitis and fungal encephalitis -- Brain aging and neurodegenerative diseases -- Future advances in liquorpheresis systems and applications -- New technical developments -- New applications.