Part I. Ventilatory Modes, Ventilators and Interfaces -- Non-Invasive Ventilation: Modes of Delivery and Interfaces -- Continuous Positive Airway Pressure - High Flow CPAP -- High Flow Nasal Cannula.-Humidification, Airway Secretions Management and Aerosol Therapy -- Part II. Methodology -- Why and When to Start Non-invasive Ventilation -- Part III. Applications of NIMV in emergency medicine and Related Issues: Pre-hospital and Emergency Medicine -- Non-invasive Mechanical Ventilation in Pre-hospital Medicine -- Current Strategies and Equipment for Non-invasive Ventilation in Emergency Medicine -- Part IV. Critical Care Applications of NIMV and Related Issues: Critical care -- Non-invasive Positive Airway Pressure and Non-invasive Ventilation in Acute Cardiogenic Pulmonary Edema -- Non-invasive Ventilation in Severe Pneumonia -- Non-invasive Ventilation in Acute and Chronic Obstructive Pulmonary Disease -- Non-invasive Ventilation and Acute Respiratory Distress Syndrome -- Non-invasive Ventilation in COVID-19 -- Non-invasive Mechanical Ventilation in Trauma -- Non-invasive Ventilation in Post-Extubation Failure -- Part V. Perioperative Applications of NIMV and Related Issues: Intra- and Postoperative Indications for noninvasive Mechanical Ventilation -- Use of Non-invasive Ventilation in Post-operative Patients in Cardiac and Thoracic Surgeries -- Use of Non-invasive Ventilation in Post-operative Patients in Abdominal Surgery -- Non-invasive Ventilation in Solid Transplantation -- Non-invasive Positive Pressure Ventilation in Patients Undergoing Lung Resection Surgery -- Part VI. Noninvasive ventilation analgesia and sedation -- Sedation and Analgesia During Non-invasive Ventilation in Intensive Care -- Part VII. Noninvasive mechanical Ventilation in palliative care -- Palliative Use of Non-invasive Ventilation -- Use of Non-invasive Mechanical Ventilation in Older Patients -- Use of Non-invasive Ventilation at the End of Life.