Part I Breast -- 1 Establishment of a medical system with HBOC in mind -- 2 Guidelines for diagnosis and treatment of HBOC: Methods and Products -- 3 RRM from a Plastic Surgery Perspective -- Part 2 Gynecology -- 4 Significance of p53 signature in RRSO samples -- 5 Mutual feedback between gynecological HBOC practice and cancer genomic medicine -- Part 3 Basic Science -- 6 Diversity of HBOC-Related Genes Revealed by Genome Analysis -- 7 New functions of BRCA1/2 regulating carcinogenesis and drug sensitivity -- Part 4 Health and Labor Sciences Research Grant -- 8 Systemic Issues in HBOC Treatment -- 9 Current status and future issues of the activities of the relevant organizations -- Part 5 Congress Award -- 10 Understanding the significance of the test in relatives of prostate and pancreatic cancer patients who tested positive on BRACAnalysis -- 11 Handling Germline Findings in Ovarian Cancer Cases -- Part 6 JOHBOC registration -- 12 JOHBOC registration data up to date 2021.