Section 1. Detection of Cholesterol Crystals-Why Was it Missing,- Chapter 1. Historical perspective -- Chapter 2. New techniques -- Section 2: Crystallography-A Molecular Perspective -- Chapter 3. Overview -- Chapter 4. Cholesterol Crystal Formation -- Section 3. Cholesterol Crystals in Atherosclerosis- Atheroma to Atherosclerosis & Beyond -- Chapter 5. Lipidology and Atherosclerosis -- Chapter 6. Studies of CCs in Cell Culture -- Chapter 7. Mechanisms of CC induced Inflammation and atherosclerosis -- Chapter 8. Rheumatology/Vascular biology - intersection of gout and atherosclerosis -- Chapter 9. Potential of Cholesterol Crystals to cause trauma -- Section 4. Cholesterol Crystal Induced Vascular Embolism & End-organ Injury -- Chapter 10. Myocardial Injury -- Chapter 11. Cerebral, Hollenhorst plaques & Amaurosis fugax, Stroke and TIA -- Chapter 12. Muscular -- Chapter 13. Cutaneous -- Chapter 14. Renal injury -- Section 5. Other Cardiac Sites of Cholesterol Crystal injury -- Chapter 15. Cardiac Valve Injury by Cholesterol Crystals -- Chapter 16. Interaction of Cholesterol Crystals and Bacteria Causing Endocarditis -- Chapter 17. Pericardial deposition -- Section 6. Interaction of Cholesterol Crystals with Other Crystalloids -- Chapter 18. Cholesterol Crystals as a nidus for calcification -- Chapter 19. Calcium phosphate crystals as inducers of inflammation -- Chapter 20. Monosodium urate crystals as triggers of inflammation -- Section 7. A Universal Role of Cholesterol Crystals Beyond Cardiac Disease -- Chapter 21. Solid Tumors with crystal induced VEGF -- Chapter 22. Alzheimer's with evidence of cholesterol crystals -- Chapter 23. Apical periodontitis -- Chapter 24. Biliary disease by cholesterol gall stones -- Chapter 25. Ocular retinal injury in diabetic retinopathy -- Section 8. Therapeutic Implications - Targeting Cholesterol Crystal Induced Disease -- Chapter 26. Lipid lowering with Statins -- Chapter 27. Anti-inflammatory Colchicine, canakinumab, Aspirin -- Chapter 28. Future Directions and Developments Cyclodextrin.