Section I. Background -- Historical Perspectives in B-Cell Lymphoma Classification: From Hodgkin to WHO -- Revisions to the Classification of Aggressive B-Cell Lymphomas -- Section II. Methods -- Cytogenetics and FISH in Precision Molecular Pathology of Aggressive B-Cell Lymphomas -- Introduction to Next Generation Sequencing -- Next Generation Sequencing-Based Methods for the Detection of B-Cell Clonality -- Next Generation Sequencing Detection of Copy Number Variants and Translocations -- RNA-Seq and RNA Expression Profiling -- Flow Cytometry Applications in the Diagnosis and Classification of Aggressive B-Cell Lymphoma -- Section III. Molecular Characteristics of Specific Large B-Cell Lymphoma Subtypes -- High-Grade B-Cell Lymphomas -- Precision Medicine in Burkitt and Burkitt-Like Lymphomas -- Precision Medicine in Diffuse Large B-Cell Lymphoma -- B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Classic Hodgkin Lymphoma -- Special Sites: Primary Mediastinal Large B-Cell Lymphoma, Primary CNS Diffuse Large B-Cell Lymphoma, and Primary Testicular Diffuse Large B-Cell Lymphoma -- Molecular Pathology of Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type -- Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified -- Lymphomatoid Granulomatosis -- T-Cell/Histiocyte-Rich Large B-Cell Lymphoma -- ALK Positive Large B-Cell Lymphoma -- HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified / KSHV/HHV8-Positive Diffuse Large B-Cell Lymphoma -- Large B-Cell Lymphomas With IRF4 Rearrangements -- Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation and Fibrin-Associated Large B-Cell Lymphoma -- Section IV. Immune Deficiency Related Lymphoproliferative Disease -- Plasmablastic Lymphoma -- Genetic Landscape of Post-Transplant Lymphoproliferative Disorders -- Epstein-Barr Virus-Positive Mucocutaneous Ulcer -- Section V. Emerging Molecular Technologies -- Circulating Tumor DNA in Lymphoma.