Part I. State of the Art -- Chapter 1. Personalized Medicine Through Artificial Intelligence: A Public Health Perspective -- Chapter 2. Artificial Intelligence and Digital Health: An International Biomedical Perspective -- Chapter 3. GDPR as a First Step Towards Free Flow of Data in Europe -- Chapter 4. Digital Therapeutics: Scientific, Technological, and Regulatory Challenges -- Chapter 5. Intelligence-Based Medicine: The Academic Perspective and Deep Humanism -- Part II. Consolidated Evidence -- Chapter 6. The Role of Big Data and Artificial Intelligence in Clinical Research and Digital Therapeutics -- Chapter 7. Systems Pharmacology for Immunotherapy: A Network Analysis of Signaling Pathways in Multiple Sclerosis for Combination Therapy Development -- Chapter 8. Approaches to Generating Virtual Patient Cohorts with Applications in Oncology -- Chapter 9. Artificial Intelligence and Deep Phenotyping in COVID-19 -- Chapter 10. Multilevel Modelling with AI: The Synergy-COPD Endeavour -- Chapter 11. Artificial Intelligence and Radiotherapy: Impact on Radiotherapy Workflow and Clinical Example -- Chapter 12. Artificial Intelligence in Surgery -- Part III. Emerging and Future Technologies -- Chapter 13. How Start-ups and Established Organisations Together Can Drive Meaningful Healthcare Innovation in Personalised Medicine and AI -- Chapter 14. Artificial Intelligence Augmented Medtech: Towards Personalized Patient Treatment -- Chapter 15. Quantum Computing: Promises and Challenges -- Chapter 16. Metaverse Means Better: How the Metaverse Continuum Is Evolving Healthcare to the Next Level -- Chapter 17. Patients' Reactions to Anthropomorphic Technologies in Healthcare. The Predictor Roles of Perceived Anthropomorphism and Human-Like Interaction: A Preliminarily Study -- Chapter 18. Some Ethical and Educational Perspectives on Using Artificial Intelligence in Personalized Medicine and Healthcare -- Chapter 19. The "Human Factor" Beyond Humans: Perspectives for an AI-Guided Personalized Medicine.