Part. I. History, Recollections, And Homages -- Paradigm Shifts in the History of Nox2 and Its Regulators: An Appreciative Critique -- The Phagocyte Oxidase: The Early Years -- Reflections on My Life in Noxes -- The Discovery and Characterisation of Nox2, a Personal Journey -- Reminiscences on Positional Cloning of X-CGD Gene (Aka CYBB, gp91phox, Nox2) -- On Katsuko Kakinuma: Spectroscopic Studies of Redox Centers in NADPH Oxidase "Identifying and Observing the Key Players That Pass an Electron to Oxygen" -- Pierre Vignais, from One Respiratory Chain to Another -- Gary M. Bokoch, the Rac-n-Rho Man: His fascination with Rho-GTPases -- History and Discovery of the Noxes: From Nox1 to the DUOXes -- Part. II. Canonical NADPH Oxidases -- NADPH Oxidase 1: At the Interface of the Intestinal Epithelium and Gut Microbiota -- Physiological Functions and Pathological Significance of NADPH Oxidase 3 -- Nox 4: From Discovery to Pathophysiology -- Nox5 - Molecular Regulation and Pathophysiology.-DUOX1 and DUOX2, DUOXA1 and DUOXA2 -- Part. III. NADPH Oxidase Regulators -- p47phox and NOXO1, the Organizer Subunits of the NADPH Oxidase 2 (Nox2) and NADPH Oxidase 1 (Nox1) -- The NADPH Oxidase Activator p67phox and Its Related Proteins -- p40phox: Composition, Function and Consequences of Its Absence -- Rho Family GTPases and their Modulators -- Part IV. Tools, Inhibitors, and Neighbors -- Tools to Identify Noxes and their Regulators -- Methods to Measure Reactive Oxygen Species Production by NADPH Oxidases -- Isoform-Selective Nox Inhibitors: Advances and Future Perspectives -- Proteins Cross-talking with Nox Complexes: The Social Life of Noxes -- Part V. Non-Mammalian NADPH Oxidases -- NADPH Oxidase-Dependent Processes in the Social Amoeba Dictyostelium Discoideum -- Discovery and Functional Analysis of the Single-Celled Yeast NADPH Oxidase, Yno1 -- NADPH Oxidases in Fungi -- Plant NADPH Oxidases -- Nematode Noxes: The DUOXes of Caenorhabditis elegans -- NADPH Oxidases in Arthropods -- NADPH Oxidases in Zebrafish -- Part VI. Structure -- Structural Insights into the Mechanism of DUOX1-DUOXA1 Complex -- Structure, Function and Mechanism of Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) Enzymes -- Part VII. Pathology -- Chronic Granulomatous Disease -- Definitive Treatments for Chronic Granulomatous Disease with a Focus on Gene Therapy -- Part VIII. Future -- Quo Vadis NADPH Oxidases: Perspectives on Clinical Translation.