Chapter 1. Editorial: 3D Skin models for cosmetic safety/ toxicity studies: Bridging established methods and novel technologies -- Chapter 2. Artificial skin models for animal-free testing: 3D Skin reconstruct approach, a journey in past two decades -- Chapter 3. Fabrication of ready-to-use ex vivo human skin models for chemical testing: current status and challenges -- Chapter 4. Human skin reconstructs model systems in mechanistic research, safety and efficacy studies of cosmetics: Pros and cons -- Chapter 5. Skin-on-a-Chip Microfluidic Devices: Production, Verification and Uses in Cosmetic Toxicology -- Chapter 6. 3D Bioprinting of skin tissue model -- Chapter 7. Solar radiations and phototoxicity of cosmetics: Avenues of in vitro skin models -- Chapter 8. Cosmetic Ingredients: Various Efficacy-Based testing methods in the 3D Skin based Model Systems -- Chapter 9. Animal component-free medium for long term maintenance of human skin explants and its application in toxicity studies of cosmetics -- Chapter 10. Regulatory requirements for safety/efficacy assessment of cosmetics/nano cosmetics products: Challenges and opportunities -- Chapter 11. Integrated approaches to testing and assessment (IATA) for cosmetic and personal health care products -- Chapter 12. Approach for in-silico validation of safety/ toxicity data for cosmetics -- Chapter 13. Role of omics approaches in the toxicity/ safety studies of cosmetics -- Chapter 14. Application of 3D skin models in safety/ toxicity of fragrances, flavors, hair dyes, preservatives and colorants -- Chapter 15. Toxicokinetic and toxicodynamic studies of cosmetics and personal health care products using 3D skin models: Progress made and path ahead.