Chapter 1_Nature of Life: Structuralism and functionalities -- Chapter 2_Nature of Relationship Between: A Genotype and A Phenotype -- Chapter 3_Nature of Genomic Architecture: A Topological Model of Genome -- Chapter 4_Biological Algorithm of Involution: Ontology of Gene Expressions -- Chapter 5_Nature of Developmental Processes in Mammals -- Chapter 6_Nature of Aging Process: Genomic Ontology of Aging -- Chapter 7_Nature of Genomic Evolution: Its imprint in Cancer -- Chapter 8_Nature of Regulatory Genome: The Evolution and Natural Selection of Genotope -- Chapter 9_Principles of Genomic Evolution.