Introduction -- Discovery and validation of biomarkers based on computational models of normal and pathological hippocampal rhythms -- DCM, Conductance based models and Clinical applications -- Computational Models of Closed-loop Deep Brain Stimulation -- A multiscale 'working brain' model -- How to render Neural Fields more realistic -- Multilevel computational modeling in epilepsy: classical studies and recent advances -- Computational modeling of neuronal dysfunction at molecular level reveals the role of single neurons in circuit functions in cerebellum granule layer -- Modeling Cortical and Thalamocortical Synaptic Loss and Compensation Mechanisms in Alzheimer's disease -- Toward Networks from Spikes -- Epileptogenic networks: applying network analysis techniques to human seizure activity.