Emerging concepts of pain therapy based on neuronal mechanisms -- The pharmacology of nociceptor priming -- Sodium channels and pain -- Role of nerve growth factor in pain -- Central sensitization in humans - assessment and pharmacology -- The role of NO in the spinal cord -- The role of the endocannabinoid system in pain -- The role of glia in the spinal cord in neuropathic and inflammatory pain -- Plasticity of inhibition in the spinal cord -- Gene regulation in nociception. Modulation of peripheral inflammation by the spinal cord -- The relationship between opioids and cytokines in the spinal cord -- The role of proteases in pain. Pain-related pharmacology in the amygdala -- Pain and itch - differences and commonalities.